NEO Lux was developed to provide an easy way to interact with Smart Contracts in the NEO blockchain using C#. It is not necessary to run a full node, because NEO Lux connects to Neon DB, which is the same API used by the Neon wallet.
NEO Flux aims to be the first lightweight C# NEO API server AllCode has started publishing to our neo-flux github repository. http://github.com/MobileAWS/neo-flux AllCode started working on neo-flux after incurring pain with neo-python due to neo-python's requirement...
It is important to specify your NEO Seed Nodes, if you want to get the NEO blockchain up and running on your machine. If you download the neo-gui from the NEO Project or neo-lux or neo-python from the City of Zion, you will run into issues synching the NEO blockchain....