It is important to specify your NEO Seed Nodes, if you want to get the NEO blockchain up and running on your machine. If you download the neo-gui from the NEO Project or neo-lux or neo-python from the City of Zion, you will run into issues synching the NEO blockchain....
Neo-lux
NEO Lux was developed to provide an easy way to interact with Smart Contracts in the NEO blockchain using C#. It is not necessary to run a full node, because NEO Lux connects to Neon DB, which is the same API used by the Neon wallet.

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